Medicinal Chemistry: Principles and Practice

  • ISBN 9780854046317
Covering key topics for drug discovery from the perspective of the practising industrial scientist and manager, this text presents all aspects of the subject of medicinal chemistry from initial lead through to final development. This edition builds on the successful foundations laid by the first edition by introducing new topics such as combinatorial chemistry, genomics and cheminformatics, alongside revised and updated original chapters. Introducing the cross-disciplinary topics needed, it embraces descriptions of targets, biology, metabolism and pharmacokinetics, genetics, patents and development chemistry. New case histories, strategy and tactics for drug discovery are also introduced. With many chapters written by practitioners from within the pharmaceutical industry, the text serves as a useful introduction to medicinal chemistry for new graduates and PhDs. It also serves to update more experienced scientists on the newer technologies in the field.
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