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Mechanisms of Injury in Renal Disease and Toxicity

  • ISBN 9780849388736
  • Author: Goldstein, Robin
  • Publ Date: 1994-08-01
  • Edition:
  • Binding: Hardback

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This work aims to promote an understanding of the pathophysiologic mechanisms mediating renal dysfunction in disease. It also provides a perspective in understanding mechanisms of chemically induced renal injury. Evolving concepts on the pathophysiology of glomerulonephritis, chronic glomerular injury, diabetic nephropathy and acute renal failure are changing the clinical management of these disease states and are fully covered in this work. Topics covered include: machanisms of acute and chronic renal failure; mechanisms of chronic glomerular injury; the role of eicosanoids in renal disease; mechanisms of chemically induced nephrotoxicity; renal drug-metabolizing enzymes in experimental animals and humans; mitrochondrial mechanisms of tubular injury; and reactive oxygen metabolites and iron in toxic acute renal failure.
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