Pharmacogenomics of Human Drug Transporters: Clinical Impacts

Author: Toshihisa Ishikawa

$225.00

0 Units in Stock

Add to Cart:

 
  • ISBN: 9780470927946
  • Author: Toshihisa Ishikawa
  • Publ Date: 2013-05-17
  • Edition:
  • Pages: 440
  • Imprint: WILEY *#
  • Status: ACT
  • ID - 5856

Table of Contents :


PREFACE vii
CONTRIBUTORS ix
CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS 1 Marianne K. DeGorter and Richard B. Kim
CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13 Liangfu Chen and Joseph W. Polli
CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39 Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei Huang
CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT 73 Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini
CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109 Toshihisa Ishikawa and Yoshihide Hayashizaki
CHAPTER 6 OATP1A2, OAT1, AND OAT3 125 Rommel G. Tirona
CHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141 J¨org K¨onig and Martin F. Fromm
CHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171 Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and Kathleen M. Giacomini
CHAPTER 9 MATE (SLC47) FAMILY 209 Atsushi Yonezawa and Ken-ichi Inui
CHAPTER 10 PEPT (SLC15A) FAMILY 223 Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato
CHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY 243 M'yriam Molina-Arcas and Marc¸al Pastor-Anglada
CHAPTER 12 P-GLYCOPROTEIN (MDR1/ABCB1) 271 Ingolf Cascorbi
CHAPTER 13 BSEP (ABCB11) 295 Bruno Stieger and Gerd A. Kullak-Ublick
CHAPTER 14 BCRP (ABCG2) 311 Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom
CHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345 Anne T. Nies
CHAPTER 16 MRP4 (ABCC4) 365 Satish B. Cheepala, Mugdha Sukthankar and John D. Schuetz
CHAPTER 17 MRP8 (ABCC11) 387 Yu Toyoda and Toshihisa Ishikawa
CHAPTER 18 FUTURE PERSPECTIVES 401 Toshihisa Ishikawa and Joseph Ware
INDEX 417

Description:

Highlighting the internationally hot topic of pharmacogenomics and its influence on drug therapy, Pharmacogenomics of Human Drug Transporters reviews individual drug transporters, including specific transporter families and clinical implications. This book serves as a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body, and the reasons why individuals differ. The authors include sufficient detail to enable non-specialists to understand the principles and techniques and provides a practical, hands-on resource for researchers in pharmaceutical industry, academic research, and government agencies.

Author Biography:


TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKENYokohama Institute and Professor of Biochemistry, MolecularBiology, and Pharmacogenomics at Yokohama City University'sGraduate School of Medicine. Previously, Dr. Ishikawa was theDirector of the Department of Research Technology Development atPfizer, Japan. A recipient of the Achievement Award from theInternational Life Sciences Institute (ILSI), Dr. Ishikawa is alsothe cofounder of the International Transporter Consortium(ITC).
RICHARD B. KIM, MD, FRCPC, is Professor and Chair of theDivision of Clinical Pharmacology and Associate Chair for Researchin the Department of Medicine at the University of Western Ontario.He is a Fellow of the American Association of PharmaceuticalScientists and an elected member of the American Society forClinical Investigation.
JORG KONIG, PhD, is Professor and Headof the Molecular Biology Laboratories in the Department of ClinicalPharmacology at the Friedrich-Alexander UniversitatErlangen-Nurnberg.


 

Estimated Delivery Times
In stock items despatched next working day
Out of stock items -locally sourced 2-5 days overseas 6-12 days
(if in stock at publisher)

Your IP Address is: 54.162.105.6
Copyright © 2003-2014 Medicalbooks Shopping Cart