Retinal Pharmacotherapy

Author: Quan Dong Nguyen


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  • ISBN: 9781437706031
  • Author: Quan Dong Nguyen
  • Publ Date: 2010-02-26
  • Edition:
  • Pages: 408
  • Imprint: SAUNDERS *#
  • Status: ACT
  • ID - 13605

Table of Contents :

1 Evolving Knowledge in Pharmacologic Treatments Section 1: Basic Sciences in Retina 2 Retinal Anatomy and Pathology 3 Retinal Biochemistry, Physiology and Cell Biology 4 Ocular Angiogenesis: Vascular Endothelial Growth Factor and Other Factors 5 Ocular Immunity and Inflammation 6 Complement Activation and Inhibition in Retinal Disease 7 Genetics of Retinal Disease Section 2: Animal Models and Routes for Retinal Drug Delivery 8 Vitamins and Supplements for Age-Related Macular Degeneration 9 Ocular Pharmacokinetic, Drug Bioavailability and Intraocular Drug Delivery Systems 0 Routes for Drug Delivery to the Eye and Retina: Intravitreal Injections and Vitrectomy 11 Routes for Drug Delivery: Topical, Transscleral, Suprachoroidal, and Intravitreal Gas-Phase Nanoparticles 12 Routes for Drug Delivery: Sustained-Release Devices 13 Microspheres and Nanotechnology for Drug Delivery 14 Thermo-sensitive Hydrogels 15 Retina and Ocular Toxicity to Ocular Application of Drugs 16 Retinal Toxicity of Systemic and Topical Medications Section 3: Retinal Diseases Amenable to Pharmacotherapy 17 Non-neovascular Age-Related Macular Degeneration 18 Neovascular Age-Related Macular Degeneration 19 Diabetic Retinopathy and Diabetic Macular Edema 20 Retinal Vein Occlusion 21 Retinal Detachment and Proliferative Vitreoretinopathy 22 Posterior Uveitis 23 Choroidal Neovascularization Secondary to Inflammation, Infection, and Myopia 24 Ocular Infection: Endophthalmitis 25 Retinopathy of Prematurity 26 Idiopathic Macular Telangiectasia 27 Neovascular Glaucoma 28 Retinal Hereditary and Degenerative / Dystrophic Diseases (non-AMD) Section 4: Drugs and Mechanisms in Retinal Diseases 29 Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in the Treatment of Retinal Diseases 30 Corticosteroids: Triamcinolone, Dexamethasone, Fluocinolone, and Others 31 Anecortave Acetate 32 Therapeutic Monoclonal Antibodies and Fragments: Bevacizumab 33 Therapeutic Monoclonal Antibodies and Fragments: Ranibizumab 34 Pathophysiology of Vascular Endothelial Growth Factor and Other Angiogenic Molecules 35 Biologic Therapies: Infliximab, Adalimumab, Etanercept, Daclizumab, and Others 36 Immunomodulatory Therapy in Uveitis 37 Fusion Proteins: VEGF-Trap 38 Aptamers and Intramers: Pegaptanib 39 Protein Kinase C Inhibitor: Ruboxistaurin 40 Small-Interference RNA Technology: SIRNA 027, Bevasiranib, and REDD14NP 41 Ocular Gene Therapy 42 Neuroprotection and Retinal Diseases 43 Photosensitizers and Photodynamic Therapy: Verteporfin 44 Chemotherapy for Malignant Intraocular Tumors 45 Antibiotics Section 5: Pharmacotherapy and Surgery 46 Rheotherapy (Rheopheresis; Therapeutical Apheresis) 47 Enzymatic Vitrectomy and Pharmacologic Vitreodynamics 48 The Use of Vital Dyes during Vitreoretinal Surgery - Chromovitrectomy 49 Epimacular and External Radiotherapy 50 Current Status of Human Retinal Pigment Epithelial Transplantation Section 6: The Last Words 51 Off-Label Drugs and the Impact of the Food and Drug Administration in the Treatment of Retinal Disease 52 Value-Based Medicine and Pharmacoeconomics 53 Future Perspectives: Agents on the Horizon


"Retinal Pharmacotherapy" is the first comprehensive book devoted to pharmacologic agents and their rationale and mechanisms of action in selected retinal and uveitic diseases. Drs. Quan Dong Nguyen, Eduardo Buchele Rodrigues, Michel Eid Farah, and William F. Mieler lead an international team of expert contributors to present up-to-date knowledge of new drugs on the market, the science behind the drugs, evidence of how the drugs work, and the reasons why they are effective or not. This user-friendly, all-in-one reference provides you with easy access to practical information on the effective and appropriate use of pharmacologic agents in the management of retinal diseases.


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