Cancer Stem Cells

Author: Vinagolu K. Rajasekhar


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  • ISBN: 9781118356166
  • Author: Vinagolu K. Rajasekhar
  • Publ Date: 2014-03-25
  • Edition:
  • Pages: 552
  • Imprint: WILEY *#
  • Status: N03
  • ID - 194269

Table of Contents :

About the Editor xi
Contributors xiii
Foreword xxi
Preface xxiii
Acknowledgments xxxv
Section I Essentials of Cancer Stem Cells and ConceptualModeling 1
1 Theoretical and Experimental Foundations of the "Cancer StemCell" Model 3 Pradeep S. Rajendran and Piero Dalerba
2 The Hallmarks of Prostate Cancer Stem Cells 17 Norman J. Maitland and Anne T. Collins
3 Self-Renewal, Induced Proliferation, and Autonomous CellGrowth Represent Distinct Modes of Cell Multiplication: Relevanceto the Cancer Stem Cell Theory 39 Dov Zipori
4 Human Embryonic Stem Cells and Cancer: Modeling Disease in aDish 49 Tamra Werbowetski-Ogilvie and Robyn McClelland
5 Cancer Stem Cell as a Result of a Reprogramming-LikeMechanism: Implications in Tumor Development and Treatment 61 J.M. Iglesias, Idoia Garcia-Ramirez, Alberto Martin-Lorenzo, L.Vellon, Lucia Ruiz-Roca, A.G. Martin, and IsidroSanchez-Garcia
6 A Cancer Stem Cell Model: An Insight into the Conversion ofInduced Pluripotent Stem Cells to Cancer Stem-Like Cells 79 Akifumi Mizutani, Ling Chen, Tomonari Kasai, Takayuki Kudoh,Hiroshi Murakami, Li Fu, and Masaharu Seno
7 Altruistic Stem Cells and Cancer Stem Cells 89 Bikul Das
8 The Emerging Concept of EMT-Induced Cancer Stem Cells107 Jeremy Bastid
9 Models to Study Chronic Myeloid Leukemia Cancer Stem Cells119 Sheela A. Abraham, Lisa Hopcroft, Ravi Bhatia, SteffenKoschmieder, Anthony D. Whetton, and Tessa L. Holyoake
10 Cancer Stem Cells in Melanoma: Biomarkers and MathematicalModels 133 Stefano Zapperi and Caterina A.M. La Porta
Section II Stem Cells in Liquid Tumors 143
11 Acute Myeloid Leukemia Stem Cells Updates andControversies 145 Stephen S. Chung and Christopher Y. Park
12 Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia161 Thorsten Raff and Monika Bruggemann
Section III Stem Cells in Solid Tumors 171
13 Lung Cancer Stem Cells and Resistance to Radiotherapy173 Scott V. Bratman and Maximilian Diehn
14 Prostate Cancer Cell Heterogeneity and Prostate Cancer StemCells 183 Mark A. Badeaux and Dean G. Tang
15 Glioblastoma Stem Cells Drive Tumor Recurrence and PatientRelapse: What's the Evidence? 193 Aneet Mann, Randy van Ommeren, Branavan Manoranjan, NicoleMcFarlane, Parvez Vora, Chitra Venugopal, and Sheila Singh
16 Stem Cells and Pancreatic Cancer 209 Susana Garcia-Silva and Christopher Heeschen
17 Melanoma Subpopulations with Cancer Stem Cell Phenotypes223 Rajasekharan Somasundaram, Nicole Facompre, and MeenhardHerlyn
18 Sarcoma Stem Cells 235 Filemon S. Dela Cruz and Igor Matushansky
Section IV Cancer Stem Cells in Tumor Metastasis Perspective247
19 Cancer Stem Cells in Metastasis and Minimal Residual Disease249 Joerg Huelsken and Albert Santamaria i Martinez
20 Role of Cancer Stem Cells in Metastasis 259 Giovanna Merchand-Reyes, Rosana Pelayo, Lenin Pavon,Richard G. Pestell, and Marco Velasco-Velazquez
21 Cancer Stem Cells and the Stromal Microenvironment 273 Li Li and David A. Margolin
22 A Perspective on Breast Cancer Malignant Progression: FromCancer Stem Cell Intra Tumor Heterogeneity to Metastasis-InitiatingCells 287 Pasquale Sansone, Vinagolu K. Rajasekhar, and JacquelineBromberg
Section V Novel and Potential Targets in Cancer Stem Cells295
23 Targeting Cancer Stem Cells Modulating Embryonic StemCell Signaling, Epigenetics, and Tumor Metabolism 297 Naoko Takebe, Pamela Jo Harris, Yutaka Kondo, Abhilasha Nair, S.Percy Ivy, and Hideyuki Saya
24 Oct4, Oct1, and Cancer Stem Cells 319 Jessica Maddox and Dean Tantin
25 The Role of Cripto-1 in Cancer and Cancer Stem Cells331 Hideaki Karasawa, Nadia P. Castro, Maria Cristina Rangel, andDavid S. Salomon
26 Leptin Signaling in the Regulation of Stem and Cancer StemCells 347 Shanchun Guo, Keshav K. Singh, James W. Lillard, and LilyYang
27 Tumor-Initiating Stem-Like Cells: Carcinogenesis throughToll-Like Receptors, Environmental Factors, and Virus 361 Keigo Machida
28 The Role of Epithelial Cell Polarity Pathways on Cancer StemCells 373 Inmaculada Banon-Rodriguez, Ilenia Bernascone, and FernandoMartin-Belmonte
29 Cancer-Initiating Cells, Exosomes, and the PremetastaticNiche 389 Margot Zoller
30 MicroRNA Therapeutics to Target Brain Tumor Stem Cells403 Derryn Xin Hui Chan, Srikanth Nama, Gopinath Sundaram, andPrabha Sampath
31 The Riboproteome Orchestrates Self-Renewal and Cell Fate inLeukemia 417 Elianna M. Amin and Michael G. Kharas
Section VI Clinical Relevance of Cancer Stem Cells inPatients 435
32 Targeting Different States of Breast Cancer Stem Cells437 Sean P. McDermott and Max S. Wicha
33 Difficulties in Targeting the Beating Heart: TherapeuticImplications of the Cancer Stem Cell Hypothesis in Melanoma451 Jennifer Makalowski and Hinrich Abken
34 Targeting Cancer Stem Cells for Overcoming Drug Resistanceand Cancer Progression 461 Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H.Sarkar
35 The Role of Cancer Stem Cells in Tumor Radioresistance473 I. Kurth, C. Peitzsch, M. Baumann, and A. Dubrovska
Index 493
Color plate located between pages 222 and 223.


Cancer Stem Cells covers a wide range of topics incancer stem cell biology, including the functional characteristicsof cancer stem cells and how they're generated, where they arelocalized, the means by which cancer stem cells can be targeted,and how cancer stem cells can be reprogrammed back to normal tissuestem cells. Each chapter begins with a brief historical note andconcept summary, followed by a description of the latest basic orclinical advance associated with the topic.

Cancer Stem Cells builds systematically fromcoverage of the basic research stage to an advanced research level,from clinical relevance to therapeutic potential, and will be avaluable resource for professionals in the fields of cancerresearch and stem cell biology.


During the last decade, the conceptual themes of stem cellbiology have been re-applied, with a new vigor, to the field ofoncology. The idea that, similar to normal tissues, tumors can beviewed as complex societies , where differentcell types are generated as the result of multi-lineagedifferentiation processes, and organize themselves in hierarchicalstructures, has now entered the realm of solid tumor biology, andaltered the way we think of cancer as a disease. Most importantly,the possibility that tumor tissues, similar to normal ones, mightbe sustained in their long-term growth by a subset of cancer cells endowed with stem cell properties (i.e. a mutated cancer stem cell population capable of bothaberrant self-renewal as well as differentiation) has importantimplications for the future development of targeted therapies. Inthis beautiful book, Dr. Vinagolu K. Rajasekhar (Memorial SloanKettering Cancer Center - New York) thoughtfully weavedtogether the perspectives and contributions from several of theleading scientists in the field. This book is both an elegantreview and a practical guide to the exciting, and still largelyuncharted, world of cancer stem cells . Ipraise the editor and the authors for this wonderful endeavor, richof provocative ideas and challenging concepts, not only for abetter understanding of basic cancer biology, but also for thefuture development of new, more effective, anti-tumortreatments. Michael F. Clarke, MD., Stanford University, Stanford,CA. USA.
The cancer stem cell (CSC) concept posits that notall cells in tumors are equal, but that dedicated cells fuel tumorgrowth. A major attraction of the CSC concept rests in theexplanations it provides for several poorly understood clinicalphenomena. The CSCs are built to last a life-time, to be resilientto electromagnetic and chemical insults, to be able to slumber forprolonged periods of time and to colonize other parts of the body.Thus, the CSC hypothesis explains why a cancer patient should neverbe considered cured, even when the initial response to radiation orchemo-therapy is encouragingly robust. The concept guides thedevelopment of more effective treatments, targeting the beating heart of the tumor: the CSC. Thisauthoritative book, written by a range of world-leading cancerresearchers, provides a comprehensive overview of the cancer stemcell, its microenvironment, and how these insights will lead tonovel clinical strategies. Hans Clevers, MD., PhD., Hubrecht Institute,Utrecht. The Netherlands.
The nature and clinical relevance of cancer stemcells are timely topics covered with an appropriately broad andinsightful brush in this comprehensive book devoted entirely tothis subject. Chapters include emerging provocative evidence that acancer stem cell, although still necessarily defined operationally,actually refers to a molecular state that may be unstable oraltered reversibly. In this respect, the cancer stem cell field hasentered a new era of complexity building on discoveries ofconcurrent intrinsic and extrinsic regulators of the stem cellstate in normal tissues. Nevertheless, in spite of this evolution,many investigations in specific types of malignancies have provenuseful and more are expected. For those wanting to stay abreast ofthe field from a basic as well as a clinical perspective, this bookwill be a welcome read and resource. Connie J. Eaves, PhD., FRSC., Terry Fox Laboratory,Vancouver, Canada.
"Cancer stem cells have moved onto center stage for those whoare interested in the behavior of solid tumors. In the context ofcarcinomas, these cells hold the prospect of explaining manyaspects of the malignant behavior of high-grade tumor cells,including their metastatic dissemination and their responsivenessto a variety of therapies. Those who are interested in developingnovel therapeutic strategies for treating solid tumors can nolonger afford to ignore these important subpopulations of cancercells, which increasingly appear to be critical determinants of thesuccess or failure of existing treatments. This volumereports on many aspects of these cells in a variety of humantumors, justifying the notion that CSCs are likely to be importantplayers in virtually all types of human tumors." Robert A. Weinberg, PhD., Whitehead Institute,Massachusetts Institute of Technology, Cambridge, MA.USA.

Author Biography:

Dr. V.K. Rajasekhar, M.Sc., M.Phil., Ph.D., is a SeniorResearch Scientist at Memorial Sloan-Kettering Cancer Center, NewYork. His work with patient derived prostate cancer stem cellxenografts, a first study in renewable Biobanking of theseclinically relevant cells, has garnered eclectic post-publicationreviews. Dr. Rajasekhar has received competitive research awardsfrom the Alexander von Humboldt Foundation, Germany, and the RobertA. Welch Foundation, Texas. He has conducted research at MDAnderson Cancer Center in Houston, University of California atIrvine, University of Freiburg in Germany, etc., and taught at theUniversity of California, Irvine and the University of Medicine andDentistry of New Jersey. Dr. Rajasekhar has served as a peerreviewer for several journals, including Stem Cells, Proceedingsof National Academy of Sciences USA, Journal of Molecular Biology,Journal of Cell Biology, Neoplasia, etc.


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