Assisted Reproduction Techniques: Challenges and Management Options

Author: Arri Coomarasamy


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  • ISBN: 9781444335552
  • Author: Arri Coomarasamy
  • Publ Date: 2012-03-02
  • Edition:
  • Pages: 466
  • Imprint: WILEY *#
  • Status: ACT
  • ID - 13915

Table of Contents :

Contributors, xi
Preface, xxii
How to use this book, xxiii
Section 1: Counseling and preparation phase
1 Risk of cancer from ovarian stimulation, 3 Nikos Kanakas, Miltiadis Pitsos and Themis Mantzavinos
2 Risk of early menopause following IVF treatment, 7 Sesh Kamal Sunkara
3 The HIV positive female, 9 Joshua U. Klein and Mark V. Sauer
4 The HIV positive male, 13 Mark V. Sauer and Joshua U. Klein
5 The hepatitis B/C carrier patient, 17 Suzanne P.M. Lutgens, I.H.M. Van Loo, E.C.M. Nelissen and G.A.J. Dunselman
6 The patient with cystic fibrosis, 21 Tarek El-Toukhy
7 The patient on medication, 25 Arri Coomarasamy
8 The patient with thrombophilia, 29 Ying C. Cheong and N.S. Macklon
9 The patient with autoimmune disorders, 34 Jos'e Bellver
10 The patient with malignant disease: fertility preservation, 38 Arri Coomarasamy
11 The patient with heart disease, 43 Natasha Thorogood and Catherine Nelson-Piercy
12 The patient with diabetes, 48 Neelam Potdar and Justin C. Konje
13 The patient with thyroid disease, 51 Shiao Chan
14 The patient with hyperprolactinemia, 56 John Ayuk
15 The patient with polycystic ovaries, 61 Adam H. Balen
16 The renal transplant patient and IVF, 65 Lynne Robinson and Clara Day
17 The patient with previous pelvic irradiation, 69 Vishvanath C. Karande
18 Fertility after chemotherapy, 73 Nivedita Reddy
19 The patient with abnormal cervical cytology, 77 Mahmood I. Shafi
20 The patient with previous borderline ovarian tumor, 80 Arri Coomarasamy and Kavita Singh
21 The patient with an endometrioma, 83 Luciano G. Nardo and Oybek Rustamov
22 The patient with cervical stenosis, 86 Khaldoun Sharif
23 Vaccination and ART, 90 Arri Coomarasamy and Dukaydah van der Berg
24 The patient with hydrosalpinx, 95 Annika Strandell
25 The patient with poor ovarian reserve, 99 Scott M. Nelson
26 The patient with congenital uterine anomalies, 105 Sarah Creighton and Lina Michala
27 The patient with congenital cervico-vaginal anomalies, 109 Sarah Creighton and Lina Michala
28 The patient with uterine fibroids, 112 Haitham Hamoda and Yakoub Khalaf
29 The patient with previous Essure(R) sterilization, 115 T. Justin Clark
30 The patient with previous endometrial ablation, 119 T. Justin Clark
31 The couple with recurrent implantation failure, 124 Tarek El-Toukhy
32 The patient with previous uterine artery embolization, 128 Haitham Hamoda and Yakoub Khalaf
33 Endometrial polyp detected during ART treatment, 131 Arri Coomarasamy
34 The obese patient, 135 Mostafa Metwally and Bolarinde Ola
35 Asherman syndrome, 139 Dan Yu, Enlan Xia and T.C. Li
36 The older patient, 142 William Ledger
37 Requests for mild or natural cycle IVF treatment, 146 Brad B. Swelstad and Suheil J. Muasher
38 The ART patient with psychosexual problems, 150 Sue Elkin
39 The patient needing third-party reproduction, 153 Madhurima Rajkhowa
40 Request for social egg freezing , 159 Valerie L. Peddie and Siladitya Bhattacharya
41 The patient with bariatric surgery, 165 Zaher O. Merhi and Harry J. Lieman
Section 2: Pituitary suppression and ovarian stimulation phase
42 Poor response during ovarian stimulation, 171 Lynne Robinson and Arri Coomarasamy
43 Ovarian stimulation for IVF in a patient with previous severe ovarian hyperstimulation syndrome, 175 Khaldoun Sharif
44 Unable to achieve pituitary down-regulation, 178 K. Jayaprakasan and Nick Raine-Fenning
45 The patient discovered pregnant during pituitary down-regulation, 184 Mohammed Khairy Mahmoud and Arri Coomarasamy
46 Ovarian cysts following pituitary down-regulation, 188 Alison Taylor
47 Poor endometrial development, 192 Lynne Robinson and Arri Coomarasamy
48 Missed IVF medications, 201 Lynne Robinson and Arri Coomarasamy
49 The patient with a history of estrogen-receptor positive cancer, 205 Murat So¨nmezer and Kutluk Oktay
50 The patient over-responding to controlled ovarian stimulation during IVF, 208 Khaldoun Sharif
Section 3: Oocyte retrieval
51 General anesthesia or sedation for oocyte retrieval?, 215 Andrew F. Malins
52 Delayed oocyte retrieval, 219 Khaldoun Sharif
53 Empty follicle syndrome, 223 George Ndukwe
54 Bleeding following oocyte retrieval, 227 Annika K. Ludwig and Barbara Sonntag
55 To flush or not to flush follicles at oocyte retrieval?, 232 Micah J. Hill and Eric D. Levens
56 Inaccessible ovaries at oocyte retrieval, 236 Hazem Al-Rumaih
57 Endometriotic cysts at oocyte retrieval, 239 Graciela Kohls and Juan A. Garc' a-Velasco
Section 4: Embryo transfer
58 Couple splitting while embryos are in storage, 245 Masoud Afnan
59 Endometrial cavity fluid identified during IVF treatment, 249 Arri Coomarasamy
60 Difficult embryo transfer, 252 Khaldoun Sharif
61 Excessive cervical mucus and retained embryo at embryo transfer, 257 Hassan N. Sallam, Ahmed F. Galal and Fady S. Moeity
62 Life after embryo transfer, 261 Kelton Tremellen
Section 5: The luteal phase
63 Vaginal bleeding in the luteal phase after IVF, 267 Carol Coughlan and Bolarinde Ola
64 Pelvic infection after IVF, 271 Muhammad Faisal Aslam
65 The patient presenting with ovarian hyperstimulation syndrome, 274 Khaldoun Sharif
66 Adnexal torsion after IVF, 279 Saioa Torrealday and Beth W. Rackow
67 Exposure to infection in the luteal phase of IVF, 283 Litha Pepas and Arri Coomarasamy
Section 6: The ART laboratory
68 Total failure of fertilization after conventional IVF - rescue ICSI, 291 A. Albert Yuzpe
69 Couples not wishing to create surplus embryos in IVF, 296 Hossam Mohamed
70 Aneuploidy screening for advanced maternal age or repeated IVF failure, 300 Haitham Hamoda and Yacoub Khalaf
71 Choosing an embryo for transfer, 304 Denny Sakkas
72 Globozoospermia, 308 Steven Mansell, Anne Rice, Catherine Beaton and Christopher L.R. Barratt
73 Total failure of fertilization after ICSI, 313 Kaoru Yanagida
74 Refreezing of embryos, 317 Jerome H. Check
75 Infection in embryo culture medium, 320 Peter M.M. Kastrop
76 ICSI or IVF in nonmale-factor infertility?, 324 Mohamed Aboulghar
77 The ART program during a natural or human-made disaster, 328 Richard P. Dickey and Carla White
78 Using the wrong sperm or embryos in IVF, 331 Khaldoun Sharif and Mutaz Al-Ahmad
Section 7: The male patient
79 Unexpected inability to produce a semen sample on the day of oocyte retrieval, 337 Khaldoun Sharif
80 The azoospermic patient, 340 Khaldoun Sharif
81 ART in men with Klinefelter syndrome, 344 Ronnie G. Fine and Darius A. Paduch
82 ART in men with 100% immotile sperm, 349 Carolina Ortega-Hrepich, Dominique Raick and Herman Tournaye
83 Request for posthumous fatherhood with perimortem surgical sperm retrieval, 353 Zamip P. Patel, Heather E. Ross and Lawrence S. Ross
84 Retrograde ejaculation and anejaculation, 360 Asif Muneer and Anthony Hirsh
85 Sperm retrieval in cancerous testes, 364 Saad Aldousari and Armand Zini
86 Leukocytospermia and ART, 367 Giuseppe Ricci
87 The infertile male patient with a genetic cause, 371 Katherine L. O Flynn O Brien and Ashok Agarwal
88 Y chromosome microdeletions and ART, 376 Sherman J. Silber
Section 8: The ART pregnancy
89 Unexpected number or gender of babies after IVF, 383 Khaldoun Sharif
90 Suspected ectopic pregnancy after IVF, 387 Vishvanath C. Karande
91 Cervical ectopic pregnancy after IVF, 391 Usha Verma
92 Heterotopic pregnancy after IVF, 396 Abdel-Maguid Ramzy
93 Multi-fetal pregnancy reduction after ART, 400 R. Katie Morris and Mark D. Kilby
94 Multiple pregnancy after IVF: to cerclage or not to cerclage? 405 Harold Gee
95 Hyperreactio luteinalis after IVF, 409 Mohammad Ebrahim Parsanezhad, Leila Forooghinia and Maryam Parsa-Nezhad
96 Lactation by a commissioning mother in surrogacy, 412 Frank P. Biervliet and Stephen L. Atkin
Section 9: General issues
97 Dealing with the emotional distress following failed IVF, 417 Linda Hammer Burns
98 IVF when the prognosis is very poor or futile, 421 Khaldoun Sharif
99 Unexpected drop in the ART clinic pregnancy rate, 425 Bulent Urman and Kayhan Yakin
100 Natural fertility after IVF, 430 Frank Nawroth and Annika K. Ludwig
Index, 433


Assisted reproduction techniques have led to the birth of 4 million babies worldwide

Assisted reproduction techniques (ART), in particular in-vitro fertilization and intra-cytoplasmic sperm injection, are the most advanced forms of infertility treatment. They involve numerous counseling, medical, surgical and laboratory-based steps. At each step various problems and complications could be encountered that challenge even the most experienced ART practitioners. Moreover, patients with complex medical disorders may require ART, presenting further challenges.

Assisted Reproduction Techniques will stimulate resourceful thinking in the ART practitioner when faced with these challenges. It outlines various management options, the reasoning behind them, and the evidence on which they are based to enable the practitioner to choose the most suitable solution for the needs of each patient.

Written by 122 internationally renowned experts, Assisted Reproduction Techniques follows the patient's journey throughout the whole ART process, with chapters on: * Counseling and preparation * Ovarian stimulation * Oocyte retrieval * Embryo transfer * The luteal phase * The ART laboratory * The male patient * The ART pregnancy

Each of the 100 concise chapters includes clinical cases, background, evidence-based practical management options, preventive measures and key-point summaries of the important details.

Assisted Reproduction Techniques gives a wide-ranging practical guide to all those wishing to support couples who cannot conceive naturally.

Author Biography:

Khaldoun Sharif, MBBCh, MD, FRCOG, MFFP, Istishari FertilityCenter, Istishari Hospital, Amman, Jordan
Arri Coomarasamy, MBChB, MD, MRCOG, Birmingham Women'sHospital, University of Birmingham, UK


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