Genetic Effects on Environmental Vulnerability to Disease: State of the Art and Future Directions

Author: Sir Michael Rutter

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  • ISBN: 9780470777800
  • Author: Sir Michael Rutter
  • Publ Date: 2008-06-06
  • Edition:
  • Pages: 232
  • Imprint: WILEY *#
  • Status: ACT
  • ID - 5821


Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:* How epidemiological cohort studies can better integrate physiological (mechanistic) measures;* How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms;* How gene hunters can benefit from recruiting samples selected for known exposures;* How environmental pathogens can be used as tools for gene hunting;* How to deal with potential spurious (statistical) interactions, and* How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).


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