Genetic Effects on Environmental Vulnerability to Disease: State of the Art and Future Directions

Author: Sir Michael Rutter


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  • ISBN: 9780470777800
  • Author: Sir Michael Rutter
  • Publ Date: 2008-06-06
  • Edition:
  • Pages: 232
  • Imprint: WILEY *#
  • Status: ACT
  • ID - 5821

Table of Contents :

1. Michael Rutter Introduction: whither gene-environment interactions? 2. Rudolf Uher Gene-environment interaction: overcoming methodological challenges Discussion 3. Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato Gene-environment interaction and behavioural disorders: a developmental perspective based on endophenotypes Discussion 4. Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory Discussion Appendix General discussion I 5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriette Riese and Catharina A. Hartman Role of gene-stress interactions in gene-finding studies Discussion 6. Kenneth A. Dodge Practice and public policy in the era of gene-environment interactions Discussion 7. Kristi B. Adamo and Frederique Tesson Gene-environment interaction and the metabolic syndrome Discussion General discussion II 8. Stephen P. Robertson and Richie Poulton Longitudinal studies of gene-environment interaction in common diseases-good value for money? Discussion 9. Kee-Seng Chia Gene-environment interactions in breast cancer Discussion 10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections Discussion 11. Steven R. Kleeberger and Hye-Youn Cho Gene-environment interactions in environmental lung diseases Discussion General discussion III 12. Fernando D. Martinez Gene-environment interaction in complex diseases: asthma as an illustrative case Discussion 13 . Michael Rutter Conclusions: taking stock and looking ahead Glossary Index of contributors Subject index


Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:* How epidemiological cohort studies can better integrate physiological (mechanistic) measures;* How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms;* How gene hunters can benefit from recruiting samples selected for known exposures;* How environmental pathogens can be used as tools for gene hunting;* How to deal with potential spurious (statistical) interactions, and* How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).


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