Viral Hepatitis

Author: Howard C. Thomas


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  • ISBN: 9780470672952
  • Author: Howard C. Thomas
  • Publ Date: 2013-10-11
  • Edition: 4
  • Pages: 620
  • Imprint: WILEY *#
  • Status: ACT
  • ID - 189856

Table of Contents :

Contributors vii
Preface xii
Section I: Introduction to Liver Biology
1 Liver regeneration and fibrosis 3 Stuart J. Forbes and Malcolm R. Alison
2 Hepatic immunology 13 Gyongyi Szabo and Johanna Bruneau
Section II: Hepatitis A Virus
3 Structure molecular virology natural history and experimental models 29 Gerardo Kaplan, Krishnamurthy Konduru, Mohanraj Manangeeswaran, Jerome Jacques, Nadia Amharref and Siham Nakamura
4 Epidemiology and prevention 43 Benjamin Cowie and Stephen A. Locarnini
Section III: Hepatitis B Virus and Other Hepadnaviridae
5 Structure and molecular virology 65 Souphalone Luangsay and Fabien Zoulim
6 Epidemiology and prevention 81 Philip R. Spradling, Dale J. Hu, and Brian J. McMahon
7 Other Hepadnaviridae (including Avihepadnaviridae and woodchuck hepatitis viruses) 96 Stephen A. Locarnini and Michael Roggendorf
8 Molecular variants of hepatitis B surface antigen (HBsAg) 107 Seyed Mohammad, Jazayeri Seyed, Moayed Alavian, Payam Dindoost, Howard C. Thomas and Peter Karayiannis
9 Molecular variants of the precore core and core promoter regions of hepatitis B virus and their clinical significance 127 Peter Karayiannis, William F. Carman and Howard C. Thomas
10 Natural history of chronic hepatitis B virus infection 143 Yun-Fan Liaw
11 Extrahepatic manifestations of hepatitis B infection 154 Christian Trepo, Majid Amiri and Loic Guillevin
12 Hepatocellular carcinoma: Molecular aspects in hepatitis B 163 Marie Annick Buendia and Pierre Tiollais
13 Murine models and human studies of pathogenesis of chronic hepatitis B 176 Juandy Jo, Anthony Tanoto Tan and Antonio Bertoletti
14 Treatment of hepatitis B 188 Hellan K. Kwon and Annfca S.F. Lok
15 Liver transplantation for chronic hepatitis B and C 203 Ed Gane
Section IV: Hepatitis C Virus
16 Structure and molecular virology 221 Michael J. McGarvey and Michael Houghton
17 Epidemiology and prevention 246 Josep Quer and Juan I. Esteban Mur
18 The immune response to HCV in acute and chronic infection 266 Robert Thimme and Salim I. Khakoo
19 Animal models of hepatitis C virus infection 280 Patrizia Farci and Jens Bukh
20 Extrahepatic manifestations of hepatitis C virus infection 295 Benjamin Maasoumy, Michael P. Manns and Markus Cornberg
21 Central nervous system complications of hepatitis C virus infection 310 Daniel M. Forton, Simon Taylor-Robinson, Markus Gess and Howard C. Thomas
22 In vitro replication models 325 Volker Lohmann, Sandra Buhler and Ralf Bartenschlager
23 Natural history of chronic HCV infection and non-invasive assessment of hepatic fibrosis 341 Laurent Castera
24 Hepatitis C and hepatocellular carcinoma 353 Hubert E. Blum
25 Treatment of hepatitis C 362 Christoph Welsch and Stefan Zeuzem Thomas Viral Hepatitis
26 Development of anti-HCV drugs 377 Esperance Schaefer and Raymond T. Chung
Section V: Hepatitis D Virus
27 Structure and molecular virology 395 Francesco Negro
28 Epidemiology and natural history 403 Heiner Wedemeyer, Svenja Hardtke and Michael P. Manns
29 Treatment of hepatitis D 410 Alessia Ciancio and Mario Rizzetto
Section VI: Hepatitis E Virus
30 Structure and molecular virology 419 Xiang-Jin Meng
31 Epidemiology experimental models and prevention: zoonotic aspects of hepatitis E 431 Subrat Kumar Panda and Satya Pavan Kumar Varma
32 Clinical and pathological features and diagnosis 442 Cyril Sieberhagen and Matthew E. Cramp
Section VII: Clinical Aspects of Viral Liver Disease
33 Clinical and diagnostic aspects of viral hepatitis 453 Cui Li Lin, Chelsea Q. Xu and Jack R. Wands
34 Treatment of acute hepatitis severe acute hepatitis and acute liver failure 468 Hans L. Tillmann and Alastair D. Smith
35 Hepatitis and hemophilia 486 Mike Makris and Geoffrey Dusheiko
36 Hepatitis in persons infected with HIV 494 Janice Main and Brendan McCarron
37 Migration hepatitis B and hepatitis C 506 Manuel Carballo, Rowan Cody and Megan Kelly
38 Occupational aspects of hepatitis 515 William L. Irving and Fortune Ncube
39 Neonatal and pediatric infection 529 Deirdre A. Kelly and C.Y. William Tong
40 Management of hepatocellular carcinoma 544 Massimo Iavarone and Massimo Colombo
41 Application of molecular biology to the diagnosis of viral hepatitis 552 Stephane Chevaliez, Christophe Rodriguez and Jean-Michel Pawlotsky
42 Disinfection and sterilization 564 Martin S. Favero and Walter W. Bond
43 Evolution of hepatitis viruses 575 Peter Simmonds and Donald B. Smith
Index 587
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The 4th edition of Viral Hepatitis covers comprehensively the entire complex field of infections caused by all of the different hepatitis viruses, which affect many millions of people throughout the world with considerable morbidity and mortality.

Howard Thomas and Arie Zuckerman are joined by Anna Lok from the USA and Stephen Locarnini from Australia as Editors. They have recruited leading researchers and physicians from many countries, who have produced an authoritative account of current knowledge and research on this important infection, including new insights into immune response to HBV and HCV.

The result is a comprehensive account on all aspects of viral hepatitis, including rapid advances in the diagnosis, management, treatment and prevention of a complex infection, which in the case of hepatitis B, C and D may lead to severe complications including chronic hepatitis, cirrhosis and hepatocellular carcinoma.

The latest edition of Viral Hepatitis offers an essential resource of current information for hepatologists, gastroenterologists, infectious diseases specialists and other clinicians, researchers, public health physicians and National and International Health Authorities.


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